Strong antiviral effect against #SarsCoV2 mediated by (one isoform of) OAS1, a classical ISG. Genetic makeup of patients in this locus predisposes them for severe #COVID19. The king of ISGs, @jschoggins, summarizes it all in this superb commentary: https://t.co/j3abyqPqrc

— The Binder Lab (@TheBinderLab) October 30, 2021